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KMID : 0363620210420030056
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Journal of Korean Oriental Medicine
2021 Volume.42 No. 3 p.56 ~ p.71
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Inhibitory Effects of GGX on Lung Injury of Chronic Obstructive Lung Disease (COPD) Mice Model
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Kim Tae-Hyun
Yang Won-Kyung
Lee Su-Won
Kim Seung-Hyun
Lyu Yee-Ran
Park Yang-Chun
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Abstract
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Objectives: This study is aimed to evaluate the protective effects of GGX on lung injury of Chronic Obstructive Lung Disease (COPD) mice model.
Materials and Methods: C57BL/6 mice were challenged with lipopolysaccharide (LPS) and cigarette smoke extract (CSE) and then treated with vehicle only (Control group), dexamethasone 3 ㎎/㎏ (Dexa group), gam-gil-tang 200 ㎎/㎏ (GGT group), GGX 100, 200, and 400 ㎎/㎏ (GGX group). After sacrifice, its bronchoalveolar lavage fluid (BALF) or lung tissue was analyzed with cytospin, Enzyme-Linked Immunosorbent Assay (ELISA), real-time polymerase chain reaction (PCR) and hematoxylin & eosin (H&E), and Masson’s trichrome staining.
Results: In the COPD model, GGX significantly inhibited the increase of neutrophils, TNF-α, IL-17A, CXCL-1, MIP2 in BALF and TNF-α, IL-1β, IL-10 mRNA expression in lung tissue. It also decreased the severity of histological lung injury.
Conclusion: This study suggests the usability of GGX for COPD patients by controlling lung tissue injury
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KEYWORD
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Chronic Obstructive Lung Disease, GGX, Herbal drug, Korean medicine
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